The DEFINE PCI study used iFR pullback to understand the rate and causes of residual ischemia in 500 patients undergoing contemporary PCI. Early results find that residual ischemia is common, and causes are treatable.1
1 in 4 patients with residual ischemia
1 in 4 patients with angiographically successful PCI left the cath lab with residual ischemia.1
Mostly due to unseen focal lesion location
Of the patients with residual ischemia, 81.6% were caused by an untreated, angiographically inapparent physiologically focal stenosis of varying location.1
If all focal lesions had been successfully treated, only 4.9% of patients would remain with residual ischemia, a reduction of 79%.1
The findings from DEFINE PCI help support the value of using advanced physiologic guidance only offered by Philips to help decide not just whether to treat, but where to treat.
Without knowing the distribution of ischemia within the vessel, important segments can be missed and left untreated.
iFR Co-registration, from Philips, helps you:
Latest Videos |view more
Video
Case review of IVUS-guided PCI of a bifurcation lesion
In this program, Professor Sharp and Dr. Gallagher will present a case of an IVUS-guided PCI of bifurcation lesion. They will discuss and demonstrate the various strategies available for this LAD/Diag bifurcation lesion and how IVUS plays ...
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Implications reveal DEFINE PCI study may lead to procedural improvements in PCI
Listen to important clinical implications of how iFR pullbacks are changing how success in PCI is assessed in the DEFINE PCI study results discussion.
Video
Find out what Drs. Allen Jeremias, Gregg Stone, Habib Samady and Manesh Patel will discuss in the TCTMD roundtable series: Is physiologic guidance the solution to residual ischemia? A closer look at DEFINE PCI.
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Listen to Drs. Allen Jeremias, Gregg Stone, Habib Samady and Manesh Patel as they discuss the results of DEFINE PCI in the TCTMD roundtable: Is physiologic guidance the solution to residual ischemia? A closer look at DEFINE PCI.
1. Jeremias A et al. The DEFINE PCI Trial: Blinded Physiological Assessment of Residual Ischemia after Successful Angiographic Percutaneous Coronary Intervention, presented at ACC 2019.
